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Index > Protein center > Ripk3(Gene name) > Rat
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  • Ripk3 (Gene name),
  • Receptor-interacting serine/threonine-protein kinase 3 (Protein name ),  RIPK3_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Ripk3(Rip3);
    Protein name:
    Receptor-interacting serine/threonine-protein kinase 3;
    Alternative:
    RIP-like protein kinase 3;Homocysteine respondent protein HCYP2;Receptor-interacting protein 3(RIP-3);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necroptosis-inducing complex. Binds TRAF2 is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes.
    Function:
    Essential for cellular necroptosis in response to TNF-alpha family of death-inducing cytokines. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
    Subcellular Location:
    Cytoplasm Cell membrane Mitochondrion
    Protein Attributes:
    Sequence length:
    478
    Sequence:
    50:
    MSSVKLWLNG | ASSISLVGSE | ELENLGFVGK | GGFGAVFRAR | HTAWNLDVAV | 
    100:
    KIVNSKKISR | EVKAMVNLRH | ENVLLLLGVT | ENLEWDYVYG | PALVTGFMEN | 
    150:
    GSLSGLLQPS | CPRPWPLLCR | LLEEVVLGMC | YLHSLNPSLL | HRDLKPSNVL | 
    200:
    LDLELHAKLA | DFGLSTFQGG | SQSGSGSGSR | DSGGTLAYLA | PELLDNDGKA | 
    250:
    SKASDVYSFG | VLVWTVLAGR | EAEVVDKTSL | IRGAVCNRQR | RPPLTELPPD | 
    300:
    SPETPGLEGL | KELMTHCWSS | EPKDRPSFQD | CESKTNNVYI | LVQDKVDAAV | 
    350:
    SKVKHYLSQY | RSSDTKLSAR | ESSQKGTEVD | CPRETIVYEM | LDRLHLEEPS | 
    400:
    GSVPERLTSL | TERRGKEASF | GHATPAGTSS | DTLAGTPQIP | HTLPSRGTTP | 
    450:
    RPAFTETPGP | DPQRNQGDGR | NSNPWYTWNA | PNPMTGLQSI | VLNNCSEVQI | 
    478:
    GQHNCMSVQP | RTAFPKKEPA | QFGRGRGW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Receptor-interacting serine/threonine-protein kinase 3
    Cat.:
    E11168h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Receptor-interacting serine/threonine-protein kinase 3
    Cat.:
    E11168m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Receptor-interacting serine/threonine-protein kinase 3
    Cat.:
    E11168r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Receptor-interacting serine/threonine-protein kinase 3
    Cat.:
    U11168r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Receptor-interacting serine/threonine-protein kinase 3
    Cat.:
    U11168h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Receptor-interacting serine/threonine-protein kinase 3
    Cat.:
    U11168m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Receptor-interacting serine/threonine-protein kinase 3
    Cat.:
    P11168Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Receptor-interacting serine/threonine-protein kinase 3
    Cat.:
    P11168Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Receptor-interacting serine/threonine-protein kinase 3
    Cat.:
    P11168Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Receptor-interacting serine/threonine-protein kinase 3
    Monoclonal Antibody for Rat Receptor-interacting serine/threonine-protein kinase 3
    Monoclonal Antibody for Rat Receptor-interacting serine/threonine-protein kinase 3
    Protein for Rat Receptor-interacting serine/threonine-protein kinase 3
    Protein for Rat Receptor-interacting serine/threonine-protein kinase 3
    Protein for Rat Receptor-interacting serine/threonine-protein kinase 3

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    Linearity
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    References
    1. 1.
      "A homocysteine-respondent gene cloned from WKY VSMCs by differential display."
      Chen K.H. , Tang J.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Wistar Kyoto.
    2. 2.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Spleen.
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